|
KMID : 0376219850220010135
|
|
Chonnam Medical Journal
1985 Volume.22 No. 1 p.135 ~ p.141
|
|
|
Effects of Anions on Deoxygenation of Hemoglobin in Intact Erythrocytes
|
|
|
|
|
Abstract
|
|
|
Sodium chloride added to a suspension of intact human erythrocytes enhanced the deoxygenation of hemoglobin in a concentration-dependent manner, and this enhancing effect was more pronounced in intact erythrocytes than in free hemoglobin solution.
The deoxygenation of hemoglobin in intact erythrocytes was also enhanced by potassium chloride, sodium acetate and sodium carbonate, but was depressed by choline chloride and sodium bicarbonate. The inhibitory effect of sodium bicarbonate was more pronounced than the effect of pH rise associated with the addition of sodium bicarbonate to the reaction mixture.
The opposite effect of chloride and bicarbonate ions on the deoxygenation of hemoglobin was discussed in connection with the "chloride-bicarbonate shift" phenomenon, and it is suggested that these anion effects might have an important role in normal oxygen transport of erythrocytes.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|